WEDNESDAY, Oct. 16 (HealthDay News) -- Undergoing multiple egg
donations does not have a negative effect on women's future
fertility, according to a preliminary new study.
This was the case even when subsequent egg-donation cycles
required significantly more gonadotropin -- a drug used to
stimulate ovulation -- according to researchers from Weill Cornell
Medical College, in New York City.
The study involved women who completed at least five
egg-donation cycles between January 2004 and April 2012. On
average, the women were 26.4 years old at the time of their first
egg donation. By the time of their fifth cycle, the average age of
the women was 28.7 years.
In conducting the study, the researchers examined the women's
anti-Mullerian hormone levels (used to measure women's response to
fertility treatments), the amount of hormonal medication they
received and how long they took it. They also examined how many
eggs were retrieved during each egg-donation cycle.
The study revealed that, over multiple cycles, the average
length of time required for stimulation ranged from 9.4 days to 10
days and the average number of eggs retrieved ranged from about 21
"This retrospective study is reassuring in that egg donors who
undergo up to six cycles do not have evidence of depleting their
ovarian reserve, which bodes well for their future fertility," Dr.
Linda Giudice, president of the American Society for Reproductive
Medicine, said in a society news release.
On the receiving end, a separate study revealed that people who
need donated eggs to conceive a child may benefit from using frozen
eggs. Researchers at Seattle Reproductive Medicine found that using
frozen eggs may be about as efficient as fresh eggs, as well as
more cost effective.
For this study, the researchers compared the outcomes of 113
fresh donor egg in vitro fertilization (IVF) cycles with 77 frozen
cycles that took place between March 2012 and February 2013.
Although pregnancy rates were 60 percent for fresh cycles and 57
percent for frozen cycles, the study revealed that patients using
frozen eggs waited a shorter time from the initial medical consult
to the start of a cycle: 217 days for fresh eggs, compared with 172
days for frozen eggs.
Frozen eggs also had much lower patient cancellation rates at
1.2 percent, compared with 12 percent for patients who'd planned to
undergo fresh cycles.
Recipients who used frozen eggs also had lower costs: $17,500
per transfer for frozen eggs and an average of more than $30,500
for each pregnancy. For those using fresh eggs, however, the cost
per transfer was nearly $30,000 with an average cost per pregnancy
of more than $49,500.
During the last six months of the study, 61 percent of all donor
egg cycles involved frozen eggs, according to the news release.
"Frozen egg banking is a promising development for patients and
donors alike," Giudice said. "Because the costs are lower and a
shorter waiting time is involved, more patients are likely to find
frozen donor eggs a very appealing alternative to fresh donor
The studies' findings were expected to be presented Wednesday at
the joint meeting of the International Federation of Fertility
Societies and the American Society for Reproductive Medicine, held
in Boston. Data and conclusions should be viewed as preliminary
until published in a peer-reviewed journal.
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