Neuroblastoma is a rare cancer that usually occurs in children under 5 years of age. The tumor is often found during infancy and may begin before birth. It typically develops in nerve tissue near the adrenal glands just above the kidneys. However, some tumors may develop in the abdomen, chest, neck, or spinal cord.
Like most cancers, neuroblastoma can eventually spread to other parts of the body. Early detection and treatment may prevent the spread of cancer.
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It is not known exactly why the tumor develops. A genetic mutation may be involved.
Neuroblastoma affects males slightly more often than females. Factors that increase the risk of neuroblastoma include:
Certain conditions such as
fetal alcohol syndrome
neurofibromatosis type 1
, Recklinghausen disease, Beckwith-Wiedemann syndrome
Exposure to certain medications and substances such as diuretics, tranquilizers, phenytoin, alcohol, or tobacco during pregnancy
Symptoms will depend on the location of the tumor and whether the cancer has spread. Some symptoms may include: Lump anywhere on the body, usually the chest, neck, or abdomenAbdominal pain—swollen abdomen in infantsPain such back or bone pain that is not explainedBowel changes and difficulty urinatingTrouble breathing or coughing
paralysisProblems with eyelids and pupilsEasy bruising or bleedingWeight lossFeverFatigueSudden involuntary jerking of muscles and random eye movements
You will be asked about your child’s symptoms and medical history. A physical exam will be done. Tests will depend on the suspected location of the tumor.
Your child's bodily fluids and tissues may be tested. This can be done with: Blood testsUrine testsBiopsyBone marrow biopsy
Images may be taken of your child's bodily structures. This can be done with: UltrasoundMRI scanCT scanMyelogramX-ray
The cancer can spread to the liver, lungs, and bones. Early detection is key to a good prognosis.
Talk with the doctor about the best treatment plan for your child. Treatment options include:
If possible, surgery may be done to remove the tumor.
is the use of drugs to kill cancer cells. The drugs enter the bloodstream and travel through the body, killing mostly cancer cells. With
radiation therapy, radiation is directed at the tumor to kill the cancer cells. Radiation therapy may be used if the cancer has spread.
During this type of
transplant, bone marrow is removed, treated, and frozen. Large doses of chemotherapy and/or radiation therapy are applied to kill the cancer cells. After treatment, the bone marrow is replaced via a vein. Transplanted bone marrow may be your child’s own bone marrow that was treated or it may be marrow from a healthy donor.
Some neuroblastomas go away on their own. It is not known why this happens.
There are no current guidelines to prevent neuroblastomas because the cause is unknown.
General information about neuroblastoma. National Cancer Institute website. Available at: http://www.cancer.gov/types/neuroblastoma/patient/neuroblastoma-treatment-pdq. Accessed June 15, 2015.
Neuroblastoma. EBSCO DynaMed website. Available at:
http://www.ebscohost.com/dynamed. Updated March 16, 2015. Accessed June 15, 2015.
Neuroblastoma. Nemours Kids Health website. Available at:
http://kidshealth.org/en/parents/neuroblastoma.html. Updated September 2014. Accessed June 15, 2015.
Last reviewed June 2016 by Mohei Abouzied, MD
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.
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