Normally, endometrial tissue is found only inside the uterus. The uterus is the reproductive organ where a fetus develops. Hormones cause the tissue to form there, preparing the body for a fertilized egg. If you do not become pregnant, the tissue leaves the body during menstruation.
In endometriosis, endometrial-like tissue is found outside the uterus. For example, it may be found on organs in the abdomen or pelvis. In these places, the tissue still responds to hormones. It swells, breaks down, and bleeds. But it is unable to leave when you menstruate. Surrounding tissue becomes inflamed. There is often scarring.
Lesions were created by swelling and breakdown of endometrial tissue outside the uterus.
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Possible causes include: Menstrual tissue backs up through the fallopian tubes and spills into the abdomenImmune system may allow the tissue to implant on other organ surfaces and develop into endometriosisLymph system may carry endometrial cells from the uterusCertain cells left behind on abdominal organs during embryonic development can turn into endometrial tissue
Hormones and growth factors cause the disease to progress.
Factors that may increase your risk of endometriosis include: Family history—a mother or sister with endometriosisEarly onset of menstruation
Not having children—Pregnancy slows or stops the disease from progressing. The condition usually resolves at
. The symptoms may return with
hormone replacement therapy
Prolonged menstrual bleeding—more than 7-8 daysAbnormal development of the uterus, with a blocked segment
Symptoms range from mild to severe. You may have many large growths with little pain. Or, you may have small areas with intense pain.
Symptoms include: Cramping and pelvic pain—especially just before and during menstrual bleeding
Pain during sex—
dyspareuniaHeavy periodsLow back painPain during bowel movements or urinationInfertilityMiscarriage
You will be asked about your symptoms and medical history. A pelvic exam will be done. These are best done early in the menstrual period. Since you may not have any symptoms, diagnosis is usually confirmed with a
. This test allows the doctor to see if there are patches of endometrial tissue and scar tissue.
The goals of treatment are to: Control painSlow endometrial growthRestore or preserve fertility
Treatment options depend on: Severity of symptomsSize, number, and location of growthsDegree of scarringExtent of the diseaseAge and whether you want to have a baby
Your doctor may recommend: Over-the-counter pain relievers to ease mild symptomsNonsteroidal anti-inflammatory drugs to reduce inflammation and help with cramping—best when taken on a regular basisPrescription pain relievers—often needed
Hormones are an option for women who are not trying to become pregnant. Birth control pills and other injectable drugs interfere with estrogen production. These medications may decrease pain and shrink the size and number of endometrial growths. But, symptoms and endometrial growths tend to come back when the hormones are stopped. If birth control pills are prescribed to manage endometriosis, then they are often used continuously, so that you do not menstruate. After surgery, birth control pills may reduce the chance of these growths returning.
If you have severe symptoms or you want to get pregnant, doctors can try to remove endometrial growths. This is often done with laparoscopic surgery. In severe, unmanageable cases it may be advised to also
remove the uterus and ovaries
. But this means that you cannot get pregnant.
There is no known way to prevent this condition.
American Academy of Family Physicians.
Endometriosis: what you should know. Am Fam Physician. 2006 Aug 15;74(4):601-2. Available at:
http://www.aafp.org/afp/2006/0815/p601.html. Accessed October 8, 2015.
The American College of Obstetricians and Gynecologists.
The Management of Endometriosis. Practice bulletin No. 114; July 2010.
Endometriosis. The National Institute of Child Health and Human Development website. Available at:
http://www.nichd.nih.gov/health/topics/endometri/Pages/default.aspx. Updated June 24, 2013. Accessed October 8, 2015.
3/12/2010 DynaMed Plus Systematic Literature Surveillance
http://www.dynamed.com/topics/dmp~AN~T115220/Endometriosis: Seracchioli R, Mabrouk M, Frascà C, et al. Long-term cyclic and continuous oral contraceptive therapy and endometrioma recurrence: a randomized controlled trial.
Last reviewed September 2015 by Andrea Chisholm, MD
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.
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